Founded ADS74 in 2022 after co-founding 7478 architects in 2015 and working at OMA/ Rem Koolhaas since 2008 as architect and project leader, with 20 years of experience in built and complex projects around the world.

These spanning from master plans such as Endurance Village in Qatar, to museums such as National Art Museum of China, mix-use buildings such as BLOX in Copenhagen or JBR1 in Dubai, as well as theaters, residential towers, office towers, hotels, retail, sport venues, educational buildings and infrastructure. 

Alessandro De Santis studied architecture at the University of Florence, Italy.